Studies allow us to conclude that in the serum of patients with generalized periodontitis on the background of overweight and obesity there is an imbalance of adipokines leptin and adiponectin. The obtained data are consistent with the literature, according to which, an increase in BMI is accompanied by an increase in leptin production and a decrease in adiponectin levels. https://www.selleckchem.com/products/ziritaxestat.html These disorders were more pronounced in patients with generalized periodontitis on the background of obesity. Such an imbalance in adipose tissue may stimulate the production of pro-inflammatory cytokines and contribute to the progression of periodontal disease in such patients.Goal - to determine efficacy of the Ileosigmo-pouch (ISP) as a method of transrectal urinary diversion in invasive bladder cancer (BC) treatment. Retrospective analysis of clinical data of patients that undergone radical cystectomy (RC), followed by ISP method of urinary diversion. Study compared two groups of patients the first group of 22 (23.6%) patients with ISP and the control group included 71 (76.4%) patients with Mainz pouch II (MP II) diversion. The groups were statistically comparable by major clinical parameters. Complication rates were evaluated with Clavien-Dindo classification. There were no significant differences in the duration of surgery procedure, - ISP 210 - 562 (380.4±38.4) minutes vs. 190 - 557 (311.3±49.5) minutes for MP II. Levels of intraoperative blood loss in both groups were comparable 110 - 2850 (707.42±97.2) ml vs. 170 - 3000 (788.51±141.3) ml. Peroiperative complications after ISP and MP II (1 (4.5%) vs. 6 (4.8%)) did not exceed 3 grade according to Clavien-Dindo. The frequency of postoperative chronic pyelonephritis (CP) was higher in MP II 26 (24.3%) vs. ISP 3 (15.7%). Gas reflux into the kidneys was observed only in MP II 18 (16.8%). Metabolic acidosis was revealed in 27 (25.2%) after MP II and in 2 (10.5%) after ISP. During the ISP formation comparing to MP II, the pouch volume increased in average up to 1000 ml vs. 750 ml., the pressure in a sigmoid colon decreases to 18 cm of water column against 35 cm wc. Urination/defecation frequency was improved in patients after ISP - every 3-4 hours during the day and 5-6 hours at night vs. MP II every 2-3 hours during the day and 3-4 hours at night. The ISP method of urinary diversion in our study showed improvements of urodynamic parameters and eliminated the body metabolic disorders when compared to transrectal diversion with MP2. This viable option of diversion in patients with invasive bladder cancer who are not candidates for neobladder, but strongly afraid of cutaneous urinary stoma.The goal of the study was to find ways to improve the quality of preoperative diagnosis of mucinous cystic liver neoplasms using such tumor markers as CA 19-9 and telomerase activity. We conducted a retrospective analysis and a prospective study that included the results of treatment of 80 patients with cystic neoplasm of the liver (31 with MCNL, 36 with multichamber non-parasitic cysts (NPC), 13 with stage II (WHO classification) echinococcus liver cysts. Our study showed the presence of telomerase activity in 29 (93.5%) patents with MCNL (in case of IMCNL, the TA was high both in the tumor itself and the CNL content).16 patients demonstrated high TA (+++) both in the tumor itself and the CNL content; 11 and 2 patients had moderate (++) and low (+) TA, respectively. 12 (38.7%) patients with MCNL had the CA 19-9 level above 1000 U/L, 14 (45.1%) - above 10,000 U/L, and 3 (9.6%) - above 100,000 U/L, while only 1 (6.5%) patient had the CA 19-9 level less then 1000 U/L. The analysis of data showed the absence of TA in the CNL content in 33 of 36 patients with NPC. However, three patients demonstrated a low activity of telomerase. CA 19-9 levels were below 1000 U/L in 27 (75%) of 36 patients with NPC. It was established that the determination of TA and the level CA 19-9 in the contents of the CNL is a valuable method, which makes it possible to carry out a preoperative differential diagnosis of CNL with a high probability.Considering an increasing the incidence of diabetes mellitus, the aim of the study was to improve the results of treatment of patients with diabetic foot syndrome due to the proposed complex VAC-associated therapy. The use of this method within 5 days of treatment was increased the local blood flow of the wounds from 26-31 to 49-53 mm Hg (p less then 0.01), while in the comparison group the blood flow was at the level of 32-37 mm Hg. The granulation tissue in the wound developed on average by 4.76±0.82 days, which is significantly faster than in the control group - 9.88±1.13 (p less then 0.05). Wound contamination of the main group was 7.9±0.26 Lg CFU/g tissue for treatment, on the 5th day - 2.8±0.23 Lg CFU/g tissue, and the regenerative-inflammatory type of cytograms prevailed in smears-prints. On the 10th day - there was no pathological microflora in the wound, marginal epithelialization appeared, a cytogram of the regenerative type. At the same time, in the comparison group, the contamination before treatment was 7.7±0.19 Lg CFU/g (p less then 0.05), and on the 5th and 10th days the indicators were significantly higher - 6.1±0.18 Lg CFU/g (p less then 0.01) and 3.2±0.17 Lg CFU/g (p less then 0.01), respectively, and the cytograms still remained of the inflammatory type. Due to the improvement of microcirculation, rapid cleaning of the wound and a decrease in local signs of inflammation, stimulation of the growth of granulation tissue, microbial decontamination and a significant reduction in the time for cleaning and healing the wound, the proposed method of combined VAC-therapy can significantly reduce the time required to prepare the wound for its healing. The proposed complex method of VAC-therapy significantly improves the healing processes of wounds and shortens the treatment time for complications of diabetes mellitus.The purpose was to study the features and results of redo laparoscopic antireflux surgery. For the period from 2008 to 2019, in Odessa Regional Hospital laparoscopic antireflux operations were performed in 1164 patients. 57 patients underwent laparoscopic reoperation during the study period based on the following indications recurrence of hiatal hernia (n=37), recurrent reflux (n=4), dysphagia (n=8), severe pain (n=5), esophageal stricture (n=3). All patients underwent repeated examinations in our clinic, telephone interviews, mailing of special questionnaires. All complaints were recorded, the quality of life was determined according to the GERD-HRQL questionnaire. All redo operations were performed laparoscopically without conversion to laparotomy. Intraoperative complications were observed in 11.11% of patients. Long-term follow up from 6 months to 6 years was observed in 90.74% of patients. The quality of life of patients according to the GERD-HRQL questionnaire significantly improved in long-term follow-up (p less then 0.